Toxicity Screening

In order to develop new green and safe pesticides, toxicity assessment is required at an early stage to improve the success rate of research and development and reduce the risk of failure. The facility provides prediction and screening of the physical and chemical properties, ADME properties, toxicology and environmental effects of candidate compounds. Services include computer aided prediction, in vitro cell - based screening and in vivo early screening experiments.

service items

1. In silicon Prediction

The self-built data platform and the public standard database were used to query the similarity compounds, and the QSAR method and the validation model were used to quickly predict the chemical, toxic and metabolic characteristics of the compounds. The service contents are as follows:

•   Database virtual screening

•   Physicochemical prediction

•   Metabolic prediction

•   Health impact prediction

•   Environmental effect prediction

2. In Vitro Screening

Through high-throughput screening platform, cell culture and molecular biology methods were applied to rapidly screen the toxicity of compounds. The mechanism of drug discovery toxicity was studied to determine the critical path of toxicity. The content of the service is as follows:

•   High content cell effect screening

•   High throughput cytotoxicity screening

•   Acute toxicity and genotoxicity

•   Reproductive toxicity and EDC screening

•   Target organ toxicity screening

3. In Vivo Screening

Model organisms such as rodents, zebrafish and transgenic organisms were used to screen compounds for toxicity. In vivo screening is to further verify the results of computer prediction and cell screening, to exclude the false positive results of screening, and to provide a reference for the pre-test of registered GLP test. The model creatures used are as follows:

•   Acute rodent toxicity

•   Aquatic toxicity screening

•   Model animal toxicity screening

•   Toxicity mechanism study

Application Field

The facility relies on computer prediction, cell culture methods, and high-throughput screening platforms to help early-stage risk decisions in drug discovery. At the same time, provide pesticide registration impurities, metabolites safety identification, research and development of new safener and formulation of toxic screening and risk prediction.

•   Screening of lead compounds

•   Toxicity prediction of impurities and metabolites

•   Toxicity assessment of safener or synergist

•   Safety screening of new formulation

Contact Us

Mr.Yan    +86   024-62353433/ 18540366326