Drug discovery and screening

Our purpose is to predicting and screening the early physicochemical properties, biological activities, ADME properties and toxicity of candidate compounds. It could improve research efficiency, reduce research risk, and guide drug chemists in rational structural optimization. We can also provide computer-assisted screening, cell-based screening and in vivo screening.

Service items

1.Computer aided screening

Hit screening in silicon

Molecular docking

Physical and chemical properties prediction

Metabolic properties prediction

Toxicity prediction

2.In vitro screening

Cell-based screening (tumor, diabetes, immunity, etc.)

High-content screening

Cytotoxicity screening（MTT、CCK-8）

Genotoxicity screening（AMES, Micronucleus assay, Chromosomal aberration test, SCGE/ comet assay）

Target organ toxicity screening(HTS)

Binding rate of plasma protein, BRPP

Cell permeability test

Metabolic stability test(Liver microsome, S9, Hepatocyte, plasma)

Metabolite identification

3.In vivo screening

Pharmacodynamic screening( tumour, bleeding and coagulation, metabolic disease, cardiovascular disease, neurological and psychiatric disease, etc.)

Single dose and cumulative toxicity screening

in vivo PK

The guidelines to be followed

Refer to the OECD related in vitro test guidelines and test methods in the literature

Qualification platform

National Shenyang Center for New Drug Safety Evaluation and Research

Key Laboratory of New Drug Safety Evaluation Technology of Liaoning Province

Biomedical Safety Evaluation Sub-platform of Liaoning Province

Equipments

Cell high content screening system, flow cytometry, multi-function microplate reader, gene chip scanner, real-time quantitative PCR, chemiluminescence imager, LC-MS/MS, etc.

Business Consulting

Ms.Li   +86   024-85869185/ 18540366476