Metabolism study in animal and crop

       The objective of pesticides metabolism study is to reveal adsorption, distribution, biotransformation and excretion of test item in animal and crop, analyze and identify metabolites, state metabolism pathway, explore kinetics of poison and metabolites. Metabolism and toxicokinetics study of pesticides TC, metabolism study in animal and plant of pesticide preparations could be performed in accordance with ICAMA GLP in our center. Our center has radiation safety license and class C unsealed radioactive material workplace, and relevant experiments could be carried out by radioisotope labeling technology.

Service items

1、Metabolism and toxicokinetics study

      Adsorption, distribution, biotransformation and excretion study of pesticides TC in rat could be carried out in accordance with ICAMA GLP (including radioisotope labeling and non- radioisotope labeling study). Analyzed and identify metabolites, state metabolism pathway and provide scientific basis for further study on toxicity mechanism and toxicity safety evaluation of the pesticides.

 

2、Pesticide metabolism study in crops

      Metabolism study of pesticides in crops could be carried out in accordance with ICAMA GLP (including radioisotope labeling and non- radioisotope labeling study). The experiment crops include fruit, root crops, leafy crops, cereal/grass crops, pulses and oilseeds, and so on. Adsorption, distribution, and transformation of pesticides in crops is studied by radioisotope labeling, chromatography and mass spectrometry technology, metabolites and metabolism pathway are stated in this study.

3、pesticide metabolism study in animal

     Metabolism study of pesticides in livestock could be carried out in accordance with ICAMA GLP (including radioisotope labeling and non- radioisotope labeling study). The experiment system include lactation goat and laying hen. Adsorption, distribution, and transformation of pesticides in animals is studied by radioisotope labeling, chromatography and mass spectrometry technology, metabolites and metabolism pathway are stated in this study.


Compliance guidelines

Toxicological Test Methods of Pesticides for Registration-Part 29: Metabolism and toxicokinetics study, GB15670.2017
Guideline for the testing of pesticide metabolism in crops, NY/T3096-2017
Guideline for the testing of pesticide metabolism in livestock, draft for comments
Toxicokinetics, OECD 417
Metabolism in Crops, OECD501
Metabolism in livestock,OECD503

Qualification platform

Class C unsealed radioactive material workplace
ICAMA GLP、OECD GLP、CFDA GLP、AAALAC
Pass the US FDA GLP inspection in 2018

Instrument and equipment

LC-MS、LC-MS、GC-MS、HPLC、UPLC、GC、LSQ、HPLC-ARC、Oxidation burner。

液体闪烁计数分析仪.jpg
LSQ

氧化燃烧仪.jpg
Oxidation burner

HPLC-在线同位素检测仪.jpg
HPLC-ARC

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LC-MS


Business consulting

Contact: Manager. Li     Tel: 024-62353476

Your cooperation intention